EGFR (Epidermal Growth Factor Receptor)
EGFR
Receptor tyrosine kinase driving cell proliferation, commonly mutated in NSCLC.
機能
Activating mutations drive oncogenic signaling. Targeted by TKIs (erlotinib, osimertinib) and antibodies (cetuximab).
この標的に作用する薬物
| 薬物 | 作用 | 主要 |
|---|---|---|
| Trastuzumab | Antagonist | はい |