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EGFR (Epidermal Growth Factor Receptor)

EGFR

Receptor tyrosine kinase driving cell proliferation, commonly mutated in NSCLC.

Function

Activating mutations drive oncogenic signaling. Targeted by TKIs (erlotinib, osimertinib) and antibodies (cetuximab).

Related Targets

ALK (Anaplastic Lymphoma Kinase) ALK BCR-ABL1 (BCR-ABL Fusion Protein) BCR-ABL1 BRAF (BRAF Kinase) BRAF CDK4/CDK6 (Cyclin-Dependent Kinase 4/6) CDK4/CDK6 MTOR (Mechanistic Target of Rapamycin) MTOR KDR (Vascular Endothelial Growth Factor Receptor 2) KDR