EGFR (Epidermal Growth Factor Receptor)
EGFR
Receptor tyrosine kinase driving cell proliferation, commonly mutated in NSCLC.
Function
Activating mutations drive oncogenic signaling. Targeted by TKIs (erlotinib, osimertinib) and antibodies (cetuximab).
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Trastuzumab | Antagonist | Yes |