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BCR-ABL1 (BCR-ABL Fusion Protein)

BCR-ABL1

Constitutively active tyrosine kinase from Philadelphia chromosome t(9;22) in CML.

Function

Imatinib was the first targeted TKI, transforming CML from fatal to manageable disease.

Related Targets

ALK (Anaplastic Lymphoma Kinase) ALK BRAF (BRAF Kinase) BRAF CDK4/CDK6 (Cyclin-Dependent Kinase 4/6) CDK4/CDK6 EGFR (Epidermal Growth Factor Receptor) EGFR MTOR (Mechanistic Target of Rapamycin) MTOR KDR (Vascular Endothelial Growth Factor Receptor 2) KDR