Azithromycin vs Metronidazole

Azithromycin vs Metronidazole: Overview

This comparison examines the pharmacological differences between Azithromycin and Metronidazole.

Mechanism of Action

Azithromycin: Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis.

Metronidazole: Forms cytotoxic free radicals that damage bacterial DNA.

Pharmacokinetics

Half-life: Azithromycin — 68 hours; Metronidazole — 8 hours.

Chemical Properties

Molecular Formula: Azithromycin — C38H72N2O12; Metronidazole — C6H9N3O3.

Molecular Weight: Azithromycin — 748.9840 g/mol; Metronidazole — 171.1540 g/mol.

Type: Azithromycin — Small molecule; Metronidazole — Small molecule.