Bupropion vs Duloxetine

## Bupropion vs Duloxetine: Overview

This comparison examines the pharmacological differences between **Bupropion** and **Duloxetine**.

## Mechanism of Action

**Bupropion**: Norepinephrine-dopamine reuptake inhibitor (NDRI).

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

## Pharmacokinetics

**Half-life**: Bupropion — 21 hours; Duloxetine — 12 hours.

## Chemical Properties

**Molecular Formula**: Bupropion — C13H18ClNO; Duloxetine — C18H19NOS.

**Molecular Weight**: Bupropion — 239.7420 g/mol; Duloxetine — 297.4150 g/mol.

**Type**: Bupropion — Small molecule; Duloxetine — Small molecule.