Canagliflozin vs Hydrochlorothiazide

## Canagliflozin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Canagliflozin** and **Hydrochlorothiazide**.

## Mechanism of Action

**Canagliflozin**: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Canagliflozin — 10.6 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Canagliflozin — C24H25FO5S; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Canagliflozin — 444.5170 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Canagliflozin — Small molecule; Hydrochlorothiazide — Small molecule.