Canagliflozin vs Metformin

## Canagliflozin vs Metformin: Overview

This comparison examines the pharmacological differences between **Canagliflozin** and **Metformin**.

## Mechanism of Action

**Canagliflozin**: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

## Pharmacokinetics

**Half-life**: Canagliflozin — 10.6 hours; Metformin — 4-9 hours.

## Chemical Properties

**Molecular Formula**: Canagliflozin — C24H25FO5S; Metformin — C4H11N5.

**Molecular Weight**: Canagliflozin — 444.5170 g/mol; Metformin — 129.1640 g/mol.

**Type**: Canagliflozin — Small molecule; Metformin — Small molecule.