Duloxetine vs Paroxetine

## Duloxetine vs Paroxetine: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Paroxetine**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Paroxetine**: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Paroxetine — 21 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Paroxetine — C19H20FNO3.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Paroxetine — 329.3730 g/mol.

**Type**: Duloxetine — Small molecule; Paroxetine — Small molecule.