Fluconazole vs Metronidazole

## Fluconazole vs Metronidazole: Overview

This comparison examines the pharmacological differences between **Fluconazole** and **Metronidazole**.

## Mechanism of Action

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

**Metronidazole**: Forms cytotoxic free radicals that damage bacterial DNA.

## Pharmacokinetics

**Half-life**: Fluconazole — 30 hours; Metronidazole — 8 hours.

## Chemical Properties

**Molecular Formula**: Fluconazole — C13H12F2N6O; Metronidazole — C6H9N3O3.

**Molecular Weight**: Fluconazole — 306.2710 g/mol; Metronidazole — 171.1540 g/mol.

**Type**: Fluconazole — Small molecule; Metronidazole — Small molecule.