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Icatibant

CHEMBL2028850 Phase 4 승인됨 Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1304.5 g/mol
LogP
-6.4
Phase
4

This synthetic peptide is used to treat acute attacks of hereditary angioedema (HAE) by blocking bradykinin B2 receptors. Bradykinin is the main mediator of the severe swelling episodes that characterize HAE, and blocking its receptor rapidly reduces swelling in the skin, abdomen, and airway. It is self-administered by subcutaneous injection at the first sign of an attack.

분자량

1304.5000 g/mol

LogP

-6.40

TPSA

552.00 Ų

리핀스키 5의 법칙

불통과

치료 영역

Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C[C@@H]2CCCC[C@@H]21

                

                

                
                

                    
InChI

                    
InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C59H89N19O13S

                    

                    
                    

                        
HBD / HBA

                        
15 / 18

                    

                    
                    

                        
회전 가능 결합

                        
30

                    

                    
                    
                    

                        
무거운 원자

                        
92

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
This synthetic peptide is used to treat acute attacks of hereditary angioedema (HAE) by blocking bradykinin B2 receptors. Bradykinin is the main mediator of the severe swelling episodes that characterize HAE, and blocking its receptor rapidly reduces swelling in the skin, abdomen, and airway. It is self-administered by subcutaneous injection at the first sign of an attack.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Icatibant is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2028850.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6918173.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.