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Isosorbide Mononitrate

CHEMBL1311 Phase 4 승인됨 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
191.1 g/mol
LogP
-0.4
Phase
4

This long-acting nitrate is used to prevent angina attacks and treat chronic heart failure by dilating blood vessels, reducing preload and afterload on the heart. It is the active metabolite of isosorbide dinitrate and has more predictable bioavailability. As with all nitrates, tolerance can develop and drug-free periods are needed to maintain effectiveness.

분자량

191.1400 g/mol

LogP

-0.40

TPSA

93.70 Ų

리핀스키 5의 법칙

통과

치료 영역

Glaucoma Cardiovascular Disease Osteoporosis Migraine Stroke Obesity Type 2 Diabetes Hypertension Atopic Dermatitis Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=[N+]([O-])O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O

                

                

                
                

                    
InChI

                    
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H9NO6

                    

                    
                    

                        
HBD / HBA

                        
1 / 6

                    

                    
                    

                        
회전 가능 결합

                        
1

                    

                    
                    
                    

                        
무거운 원자

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
This long-acting nitrate is used to prevent angina attacks and treat chronic heart failure by dilating blood vessels, reducing preload and afterload on the heart. It is the active metabolite of isosorbide dinitrate and has more predictable bioavailability. As with all nitrates, tolerance can develop and drug-free periods are needed to maintain effectiveness.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Isosorbide Mononitrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1311.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 27661.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.