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Isosorbide Mononitrate

CHEMBL1311 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
191.1 g/mol
LogP
-0.4
Phase
4

This long-acting nitrate is used to prevent angina attacks and treat chronic heart failure by dilating blood vessels, reducing preload and afterload on the heart. It is the active metabolite of isosorbide dinitrate and has more predictable bioavailability. As with all nitrates, tolerance can develop and drug-free periods are needed to maintain effectiveness.

分子量

191.1400 g/mol

LogP

-0.40

TPSA

93.70 Ų

Lipinski 五规则

符合

治疗领域

Glaucoma Cardiovascular Disease Osteoporosis Migraine Stroke Obesity Type 2 Diabetes Hypertension Atopic Dermatitis Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

                    
O=[N+]([O-])O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O

                

                

                
                

                    
InChI

                    
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H9NO6

                    

                    
                    

                        
HBD / HBA

                        
1 / 6

                    

                    
                    

                        
可旋转键数

                        
1

                    

                    
                    
                    

                        
重原子数

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This long-acting nitrate is used to prevent angina attacks and treat chronic heart failure by dilating blood vessels, reducing preload and afterload on the heart. It is the active metabolite of isosorbide dinitrate and has more predictable bioavailability. As with all nitrates, tolerance can develop and drug-free periods are needed to maintain effectiveness.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Isosorbide Mononitrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1311.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 27661.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.