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Piperonyl Butoxide

CHEMBL1201131 Phase 4 승인됨 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
338.4 g/mol
LogP
3.7
Phase
4

Piperonyl butoxide is a synergist compound that inhibits cytochrome P450 and other oxidative enzymes in insects, thereby preventing the metabolic detoxification of pyrethroid and other insecticide agents and markedly enhancing their insecticidal activity. It is widely used in combination with pyrethrins or permethrin in topical antiparasitic products for head lice, scabies, and malaria vector control.

분자량

338.4000 g/mol

LogP

3.70

TPSA

46.20 Ų

리핀스키 5의 법칙

통과

치료 영역

Malaria

작용 기전

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

기전

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2

                

                

                
                

                    
InChI

                    
InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H30O5

                    

                    
                    

                        
HBD / HBA

                        
- / 5

                    

                    
                    

                        
회전 가능 결합

                        
13

                    

                    
                    
                    

                        
무거운 원자

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
Piperonyl butoxide is a synergist compound that inhibits cytochrome P450 and other oxidative enzymes in insects, thereby preventing the metabolic detoxification of pyrethroid and other insecticide agents and markedly enhancing their insecticidal activity. It is widely used in combination with pyrethrins or permethrin in topical antiparasitic products for head lice, scabies, and malaria vector control.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Piperonyl Butoxide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201131.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5794.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.