💊 의약품 A-Z 🧬 표적 🛠 도구 📚 가이드
전체 의약품 약물 분류 치료 영역 부작용
가이드 용어집 연대표
비교 약물 체내 여정 약물 계열
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Prednisone

CHEMBL635 Phase 4 승인됨 Small molecule
Half-Life
2-3 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
358.4 g/mol
LogP
1.5
Phase
4

A synthetic corticosteroid, prednisone acts on the glucocorticoid receptor to suppress inflammation and dampen overactive immune responses. It is prescribed across a broad range of conditions, from asthma and allergic reactions to arthritis, autoimmune diseases, and certain cancers. Structurally it is a pregnane derivative with the molecular formula C21H26O5, marketed under names including Deltasone, Rayos, and Sterapred. Prolonged use affects bone density, blood glucose, and immune function, so extended courses are accompanied by monitoring. Its potency and versatility have made it one of the most widely used systemic steroids in clinical medicine.

A widely used corticosteroid that reduces inflammation and calms overactive immune responses, prescribed for conditions ranging from asthma and allergic reactions to arthritis, certain cancers, and autoimmune diseases. Long-term use requires careful monitoring as it can affect bone density, blood sugar, and immune function.

분자량

358.4280 g/mol

LogP

1.50

TPSA

91.70 Ų

리핀스키 5의 법칙

통과

치료 영역

Respiratory Disease Immunology Asthma Rheumatology

약물 분류

H — H - Systemic Hormonal Preparations, Excluding Sex Hormones and Insulins

작용 기전

Synthetic corticosteroid; suppresses inflammation via glucocorticoid receptor.

Pharmacokinetics (PK)

Half-Life 2-3 hours

Pharmacodynamics (PD)

기전

Synthetic corticosteroid; suppresses inflammation via glucocorticoid receptor.

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

                

                

                
                

                    
InChI

                    
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H26O5

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
회전 가능 결합

                        
2

                    

                    
                    
                    

                        
무거운 원자

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Moderate


                            
                                Prednisone + Warfarin
                            
                        

                        
                        
Corticosteroids have a complex and variable interaction with warfarin; high doses may increase bleeding risk via GI mucosal effects while also affecting clotting factor synthesis.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Prednisone + Levothyroxine
                            
                        

                        
                        
Supraphysiologic doses of corticosteroids such as prednisone can suppress TSH secretion and reduce T4-to-T3 conversion, complicating thyroid function interpretation during steroid courses.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Prednisone + Ibuprofen
                            
                        

                        
                        
Combining ibuprofen with corticosteroids dramatically increases the risk of GI ulcers and hemorrhage beyond the risk of either agent alone.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Prednisone + Aspirin
                            
                        

                        
                        
Prednisone may increase salicylate clearance, reducing aspirin's anti-inflammatory efficacy, and combined GI toxicity is substantially increased.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Prednisone + Metformin
                            
                        

                        
                        
Prednisone causes dose-dependent hyperglycaemia that can overcome metformin's glucose-lowering capacity, resulting in poorly controlled blood glucose, particularly postprandially.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Prednisone + Pembrolizumab
                            
                        

                        
                        
Prednisone at immunosuppressive doses may blunt pembrolizumab's anti-tumour efficacy by dampening the T-cell responses required for checkpoint inhibitor activity.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
A widely used corticosteroid that reduces inflammation and calms overactive immune responses, prescribed for conditions ranging from asthma and allergic reactions to arthritis, certain cancers, and autoimmune diseases. Long-term use requires careful monitoring as it can affect bone density, blood sugar, and immune function.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Synthetic corticosteroid; suppresses inflammation via glucocorticoid receptor.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Prednisone: Half-life: 2-3 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Prednisone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Levothyroxine
                            Small molecule
                        
                        
                        
                            Dexamethasone
                            Small molecule
                        
                        
                        
                            Methylprednisolone
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL635.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5865.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.