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Sarecycline

CHEMBL2364632 Phase 4 승인됨 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
487.5 g/mol
LogP
1.1
Phase
4

Sarecycline is a narrow-spectrum tetracycline-class antibiotic with anti-inflammatory properties, approved for the treatment of inflammatory lesions of non-nodular moderate-to-severe acne vulgaris. Unlike broad-spectrum tetracyclines, its narrow spectrum reduces disruption of gut microbiota while inhibiting bacterial protein synthesis via binding to the 30S ribosomal subunit. Investigational use in stroke has been proposed based on its matrix metalloproteinase inhibitory and anti-neuroinflammatory properties.

분자량

487.5000 g/mol

LogP

1.10

TPSA

174.00 Ų

리핀스키 5의 법칙

통과

치료 영역

Stroke

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D 구조

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CON(C)Cc1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O

                

                

                
                

                    
InChI

                    
InChI=1S/C24H29N3O8/c1-26(2)18-13-8-11-7-12-10(9-27(3)35-4)5-6-14(28)16(12)19(29)15(11)21(31)24(13,34)22(32)17(20(18)30)23(25)33/h5-6,11,13,18,28,30-31,34H,7-9H2,1-4H3,(H2,25,33)/t11-,13-,18-,24-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H29N3O8

                    

                    
                    

                        
HBD / HBA

                        
5 / 10

                    

                    
                    

                        
회전 가능 결합

                        
5

                    

                    
                    
                    

                        
무거운 원자

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
자주 묻는 질문

                

                    
                    

                        
                        

                            
Sarecycline is a narrow-spectrum tetracycline-class antibiotic with anti-inflammatory properties, approved for the treatment of inflammatory lesions of non-nodular moderate-to-severe acne vulgaris. Unlike broad-spectrum tetracyclines, its narrow spectrum reduces disruption of gut microbiota while inhibiting bacterial protein synthesis via binding to the 30S ribosomal subunit. Investigational use in stroke has been proposed based on its matrix metalloproteinase inhibitory and anti-neuroinflammatory properties.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sarecycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2364632.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 54681908.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
의학적 면책조항

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.