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Trastuzumab

CHEMBL1201585 Phase 4 승인됨 Antibody
Half-Life
28 days
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

This monoclonal antibody targets HER2, a protein that is overexpressed in certain breast and gastric cancers, and is used to treat HER2-positive cancers either alone or in combination with chemotherapy. It works by attaching to HER2 receptors on cancer cells, blocking growth signals and marking the cells for destruction by the immune system. Before starting treatment, the heart must be evaluated as trastuzumab can cause a reduction in heart function.

치료 영역

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Benign Prostatic Hyperplasia Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Neurology Psychiatry Endocrinology Respiratory Disease Dermatology Hematology Pain Management Ophthalmology Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Asthma Chronic Obstructive Pulmonary Disease Immunology Alzheimer's Disease Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Melanoma Hepatology Oncology Nephrology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Psoriasis Obstetrics & Gynecology Anesthesiology Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Urology Stroke Deep Vein Thrombosis / Pulmonary Embolism Hyperlipidemia Obesity Lymphoma Gastroenterology Rheumatology Transplant Medicine Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Atopic Dermatitis Gout Chronic Pain Malaria HIV/AIDS Hepatitis C Tuberculosis Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

약물 분류

L — L - Antineoplastic and Immunomodulating Agents

작용 기전

Anti-HER2 monoclonal antibody inhibiting receptor signaling.

Pharmacokinetics (PK)

Half-Life 28 days

Pharmacodynamics (PD)

기전

Anti-HER2 monoclonal antibody inhibiting receptor signaling.

HBD / HBA

- / -

EGFR (Epidermal Growth Factor Receptor) Antagonist
Primary Target
Minor Trastuzumab + Doxycycline

Doxycycline has been investigated as a complementary agent in HER2-positive breast cancer; its anti-mitochondrial and anti-stem-cell properties may modestly enhance trastuzumab activity without clinically significant adverse pharmacokinetic interaction.

No side effects recorded

Side effect data is not yet available for this drug.

자주 묻는 질문

This monoclonal antibody targets HER2, a protein that is overexpressed in certain breast and gastric cancers, and is used to treat HER2-positive cancers either alone or in combination with chemotherapy. It works by attaching to HER2 receptors on cancer cells, blocking growth signals and marking the cells for destruction by the immune system. Before starting treatment, the heart must be evaluated as trastuzumab can cause a reduction in heart function.

Anti-HER2 monoclonal antibody inhibiting receptor signaling.

Key pharmacokinetic parameters for Trastuzumab: Half-life: 28 days.

Yes, Trastuzumab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

ADME Journey →

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{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201585. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

의학적 면책조항

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.