Viomycin
Viomycin is a cyclic peptide antibiotic produced by Streptomyces species that inhibits bacterial protein synthesis by binding to the 30S and 50S ribosomal subunits and blocking translocation, with particular activity against mycobacteria including Mycobacterium tuberculosis. It was used as a second-line antituberculosis agent for drug-resistant TB before the development of modern combination regimens. Its nephrotoxicity and ototoxicity limit its clinical application.
분자량
685.7000 g/mol
LogP
-7.00
TPSA
393.00 Ų
리핀스키 5의 법칙
불통과
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D 구조
Cite this structure
Embed this structure
SMILES
NCCC[C@H](N)CC(=O)N[C@H]1CNC(=O)[C@H]([C@H]2C[C@H](O)NC(N)=N2)NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC1=O
InChI
InChI=1S/C25H43N13O10/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48)/b13-7-/t10-,11+,12-,14-,15-,17-,18-/m0/s1
Molecular Formula
C25H43N13O10
HBD / HBA
15 / 13
회전 가능 결합
10
무거운 원자
48
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
Viomycin is a cyclic peptide antibiotic produced by Streptomyces species that inhibits bacterial protein synthesis by binding to the 30S and 50S ribosomal subunits and blocking translocation, with particular activity against mycobacteria including Mycobacterium tuberculosis. It was used as a second-line antituberculosis agent for drug-resistant TB before the development of modern combination regimens. Its nephrotoxicity and ototoxicity limit its clinical application.
Yes, Viomycin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3085436. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135398671. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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