Zimeldine Hydrochloride
Zimeldine hydrochloride is the hydrochloride salt of zimeldine, the first SSRI developed, which selectively inhibits the serotonin transporter to increase synaptic serotonin availability for antidepressant effects. It was withdrawn from the market due to cases of Guillain-Barré syndrome and other hypersensitivity-related neurological adverse events. Its development and withdrawal provided critical lessons for the subsequent design and safety monitoring of the SSRI drug class.
분자량
408.2000 g/mol
TPSA
17.10 Ų
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D 구조
Cite this structure
Embed this structure
SMILES
CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1.Cl.Cl.O
InChI
InChI=1S/C16H17BrN2.2ClH.H2O/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;;/h3-10,12H,11H2,1-2H3;2*1H;1H2/b16-9-;;;
Molecular Formula
C16H21BrCl2N2O
HBD / HBA
3 / 3
회전 가능 결합
4
무거운 원자
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
Zimeldine hydrochloride is the hydrochloride salt of zimeldine, the first SSRI developed, which selectively inhibits the serotonin transporter to increase synaptic serotonin availability for antidepressant effects. It was withdrawn from the market due to cases of Guillain-Barré syndrome and other hypersensitivity-related neurological adverse events. Its development and withdrawal provided critical lessons for the subsequent design and safety monitoring of the SSRI drug class.
Yes, Zimeldine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2355333. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6420041. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="zimeldine-hydrochloride"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/zimeldine-hydrochloride/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/zimeldine-hydrochloride/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/zimeldine-hydrochloride/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="zimeldine-hydrochloride"></drugfyi-drug>