Zimeldine Hydrochloride

CHEMBL2355333 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

408.2 g/mol

LogP

—

Phase

4

Zimeldine hydrochloride is the hydrochloride salt of zimeldine, the first SSRI developed, which selectively inhibits the serotonin transporter to increase synaptic serotonin availability for antidepressant effects. It was withdrawn from the market due to cases of Guillain-Barré syndrome and other hypersensitivity-related neurological adverse events. Its development and withdrawal provided critical lessons for the subsequent design and safety monitoring of the SSRI drug class.

Peso Molecular

408,2000 g/mol

TPSA

17,10 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1.Cl.Cl.O

InChI

InChI=1S/C16H17BrN2.2ClH.H2O/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;;/h3-10,12H,11H2,1-2H3;2*1H;1H2/b16-9-;;;

Molecular Formula

C16H21BrCl2N2O

HBD / HBA

3 / 3

Ligações Rotacionáveis

4

Átomos Pesados

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Zimeldine hydrochloride is the hydrochloride salt of zimeldine, the first SSRI developed, which selectively inhibits the serotonin transporter to increase synaptic serotonin availability for antidepressant effects. It was withdrawn from the market due to cases of Guillain-Barré syndrome and other hypersensitivity-related neurological adverse events. Its development and withdrawal provided critical lessons for the subsequent design and safety monitoring of the SSRI drug class.

Yes, Zimeldine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2355333. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6420041. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

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Zimeldine Hydrochloride no PillFYI

Estrutura

Dados Rápidos

Fórmula: C16H21BrCl2N2O

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.