Drug-Induced Liver Injury (DILI)
DILIHepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).
예시
- Acetaminophen (dose-dependent)
- Isoniazid (idiosyncratic)
- Hy's Law: ALT >3x + bilirubin >2x
알고 계셨나요?
Hepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).