Drug Candidate
A compound that has successfully completed lead optimization and is selected for advancement into IND-enabling studies and subsequent clinical development. Must demonstrate an acceptable balance of potency, selectivity, PK properties, safety margins, and manufacturability. Typically only 1-2 drug candidates emerge from thousands of initial screening hits per program.
예시
- Candidate nomination for Phase I clinical trial
- Backup candidate in case of primary candidate failure
- Development candidate profile: IC50 <10 nM, F >30%, t1/2 >4h
알고 계셨나요?
A compound that has successfully completed lead optimization and is selected for advancement into IND-enabling studies and subsequent clinical development. Must demonstrate an acceptable balance of potency, selectivity, PK properties, …