Minor
Established
설명
Low-dose aspirin reduces the uricosuric effect of allopurinol and may increase uric acid levels, potentially triggering gout flares.
기전
Salicylates compete with uric acid for renal tubular secretion at low doses, reducing uric acid excretion and partially antagonizing allopurinol's ability to lower serum uric acid.
임상적 중요성
The interaction is most relevant with aspirin doses >1 g/day; low-dose aspirin (81–325 mg) has a smaller but still measurable effect on uric acid.
관리 방법
Monitor serum uric acid levels; consider increasing allopurinol dose if uric acid rises above target. Use acetaminophen preferentially in gout patients.