Allopurinol
A xanthine oxidase inhibitor that reduces the production of uric acid in the body, used primarily to prevent gout attacks and kidney stones caused by uric acid crystal buildup in joints and the urinary tract. It is also used to prevent elevated uric acid levels during cancer treatment when chemotherapy causes rapid breakdown of cancer cells.
분자량
136.1120 g/mol
LogP
-0.70
TPSA
70.10 Ų
리핀스키 5의 법칙
통과
치료 영역
약물 분류
작용 기전
Xanthine oxidase inhibitor reducing uric acid production.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Xanthine oxidase inhibitor reducing uric acid production.
2D 구조
Cite this structure
Embed this structure
SMILES
Oc1ncnc2[nH]ncc12
InChI
InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
Molecular Formula
C5H4N4O
HBD / HBA
2 / 3
회전 가능 결합
0
무거운 원자
10
The combination of allopurinol and amoxicillin is associated with a markedly increased incidence of skin rashes (primarily maculopapular), though the rash is usually non-severe and reversible.
Low-dose aspirin reduces the uricosuric effect of allopurinol and may increase uric acid levels, potentially triggering gout flares.
No side effects recorded
Side effect data is not yet available for this drug.
자주 묻는 질문
A xanthine oxidase inhibitor that reduces the production of uric acid in the body, used primarily to prevent gout attacks and kidney stones caused by uric acid crystal buildup in joints and the urinary tract. It is also used to prevent elevated uric acid levels during cancer treatment when chemotherapy causes rapid breakdown of cancer cells.
Xanthine oxidase inhibitor reducing uric acid production.
Key pharmacokinetic parameters for Allopurinol: Half-life: 1-2 hours.
Yes, Allopurinol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1467. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135401907. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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