Moderate
Probable
설명
Quetiapine's anticholinergic properties antagonize the pro-cholinergic mechanism of donepezil, potentially impairing cognitive benefits in dementia.
기전
Donepezil inhibits acetylcholinesterase to increase synaptic acetylcholine; quetiapine's muscarinic receptor blockade directly opposes this effect, reducing cholinergic neurotransmission.
임상적 중요성
Pharmacodynamic antagonism may impair the cognitive benefits of donepezil; additionally, sedation and delirium risk increase.
관리 방법
Use with caution; prefer antipsychotics with low anticholinergic burden for behavioral symptoms in dementia; monitor cognitive status closely.