Moderate
Probable
描述
Quetiapine's anticholinergic properties antagonize the pro-cholinergic mechanism of donepezil, potentially impairing cognitive benefits in dementia.
机制
Donepezil inhibits acetylcholinesterase to increase synaptic acetylcholine; quetiapine's muscarinic receptor blockade directly opposes this effect, reducing cholinergic neurotransmission.
临床意义
Pharmacodynamic antagonism may impair the cognitive benefits of donepezil; additionally, sedation and delirium risk increase.
处理措施
Use with caution; prefer antipsychotics with low anticholinergic burden for behavioral symptoms in dementia; monitor cognitive status closely.