Moderate
Established
설명
Naproxen reduces the diuretic and antihypertensive efficacy of thiazide diuretics, blunting blood pressure control.
기전
Thiazide diuretics rely on prostaglandin-mediated renal vasodilation for natriuresis; NSAID-mediated prostaglandin inhibition attenuates this mechanism, reducing diuretic response.
임상적 중요성
Systolic blood pressure may increase 3–6 mmHg; inadequate volume reduction may result in edema and hypertension.
관리 방법
Prefer acetaminophen for analgesia; if NSAID is used, monitor blood pressure and consider increasing the antihypertensive dose temporarily.