Moderate
Established
Mô tả
Naproxen reduces the diuretic and antihypertensive efficacy of thiazide diuretics, blunting blood pressure control.
Cơ chế
Thiazide diuretics rely on prostaglandin-mediated renal vasodilation for natriuresis; NSAID-mediated prostaglandin inhibition attenuates this mechanism, reducing diuretic response.
Ý nghĩa lâm sàng
Systolic blood pressure may increase 3–6 mmHg; inadequate volume reduction may result in edema and hypertension.
Xử trí
Prefer acetaminophen for analgesia; if NSAID is used, monitor blood pressure and consider increasing the antihypertensive dose temporarily.