Metformin vs Topiramate

## Metformin vs Topiramate: Overview

This comparison examines the pharmacological differences between **Metformin** and **Topiramate**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

**Topiramate**: Multiple mechanisms: Na+ channel block, GABA enhancement, glutamate inhibition.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Topiramate — 21 hours.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Topiramate — C12H21NO8S.

**Molecular Weight**: Metformin — 129.1640 g/mol; Topiramate — 339.3630 g/mol.

**Type**: Metformin — Small molecule; Topiramate — Small molecule.