Sildenafil vs Spironolactone

## Sildenafil vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Sildenafil** and **Spironolactone**.

## Mechanism of Action

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Sildenafil — 4 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Sildenafil — C22H30N6O4S; Spironolactone — C24H32O4S.

**Molecular Weight**: Sildenafil — 474.5800 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Sildenafil — Small molecule; Spironolactone — Small molecule.