Aliskiren Fumarate

CHEMBL3545059 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

1219.6 g/mol

LogP

—

Phase

4

The fumarate salt form of aliskiren, a first-in-class direct renin inhibitor used to treat hypertension by blocking the initial step of the blood pressure-regulating renin-angiotensin system. This salt form ensures appropriate bioavailability of the drug for once-daily oral dosing.

Peso Molecular

1219,6000 g/mol

TPSA

367,00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC.COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC.O=C(O)/C=C/C(=O)O

InChI

InChI=1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1

Molecular Formula

C64H110N6O16

HBD / HBA

10 / 18

Ligações Rotacionáveis

40

Átomos Pesados

86

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

The fumarate salt form of aliskiren, a first-in-class direct renin inhibitor used to treat hypertension by blocking the initial step of the blood pressure-regulating renin-angiotensin system. This salt form ensures appropriate bioavailability of the drug for once-daily oral dosing.

Yes, Aliskiren Fumarate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545059. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6918427. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estrutura

Dados Rápidos

Fórmula: C64H110N6O16

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.