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Amiloride Hydrochloride

CHEMBL1398126 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
302.1 g/mol
LogP
—
Phase
4

The hydrochloride salt form of amiloride, an epithelial sodium channel blocker that promotes urine production while preserving potassium levels in the body. This formulation is used in combination diuretic regimens for hypertension and edema management.

Peso Molecular

302,1200 g/mol

TPSA

161,00 Ų

Áreas Terapêuticas

Migraine Bipolar Disorder Gastroesophageal Reflux Disease Multiple Sclerosis Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Breast Cancer Heart Failure Cardiovascular Disease

Mecanismo de Ação

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cl.N=C(N)NC(=O)c1nc(Cl)c(N)nc1N.O.O

                

                

                
                

                    
InChI

                    
InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H13Cl2N7O3

                    

                    
                    

                        
HBD / HBA

                        
7 / 7

                    

                    
                    

                        
Ligações Rotacionáveis

                        
1

                    

                    
                    
                    

                        
Átomos Pesados

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
The hydrochloride salt form of amiloride, an epithelial sodium channel blocker that promotes urine production while preserving potassium levels in the body. This formulation is used in combination diuretic regimens for hypertension and edema management.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Amiloride Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1398126.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 68540.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.