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Articaine

CHEMBL1093 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
284.4 g/mol
LogP
2.8
Phase
4

A local anesthetic belonging to the amide class that blocks sodium channels in nerve membranes, preventing pain signals from being transmitted to the brain. It is widely used in dental procedures and is noted for its ability to penetrate bone tissue effectively.

Peso Molecular

284,3800 g/mol

LogP

2,80

TPSA

95,70 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Pain Management Generalized Anxiety Disorder Hypertension Chronic Pain

Mecanismo de Ação

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC

                

                

                
                

                    
InChI

                    
InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H20N2O3S

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
Ligações Rotacionáveis

                        
7

                    

                    
                    
                    

                        
Átomos Pesados

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A local anesthetic belonging to the amide class that blocks sodium channels in nerve membranes, preventing pain signals from being transmitted to the brain. It is widely used in dental procedures and is noted for its ability to penetrate bone tissue effectively.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Articaine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1093.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 32170.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.