Atogepant
A calcitonin gene-related peptide (CGRP) receptor antagonist taken by mouth that blocks CGRP signaling, a key driver of migraine pain and sensitization. It is approved as a preventive treatment to reduce the frequency of episodic and chronic migraines.
Peso Molecular
603,5000 g/mol
LogP
3,40
TPSA
104,00 Ų
Regra dos 5 de Lipinski
Reprovado
Áreas Terapêuticas
Mecanismo de Ação
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
C[C@@H]1[C@H](c2c(F)ccc(F)c2F)C[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F
InChI
InChI=1S/C29H23F6N5O3/c1-13-16(22-18(30)4-5-19(31)23(22)32)8-20(26(42)40(13)12-29(33,34)35)38-25(41)15-7-14-9-28(10-21(14)37-11-15)17-3-2-6-36-24(17)39-27(28)43/h2-7,11,13,16,20H,8-10,12H2,1H3,(H,38,41)(H,36,39,43)/t13-,16-,20+,28+/m1/s1
Molecular Formula
C29H23F6N5O3
HBD / HBA
2 / 11
Ligações Rotacionáveis
4
Átomos Pesados
43
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A calcitonin gene-related peptide (CGRP) receptor antagonist taken by mouth that blocks CGRP signaling, a key driver of migraine pain and sensitization. It is approved as a preventive treatment to reduce the frequency of episodic and chronic migraines.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Atogepant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3991065. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 72163100. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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