Bendroflumethiazide
A thiazide diuretic that reduces blood pressure by increasing urinary sodium and water excretion, decreasing blood volume and vascular resistance. It is used for hypertension and edema associated with heart failure.
Peso Molecular
421,4000 g/mol
LogP
1,20
TPSA
135,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC(Cc1ccccc1)NS2(=O)=O
InChI
InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
Molecular Formula
C15H14F3N3O4S2
HBD / HBA
3 / 10
Ligações Rotacionáveis
3
Átomos Pesados
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A thiazide diuretic that reduces blood pressure by increasing urinary sodium and water excretion, decreasing blood volume and vascular resistance. It is used for hypertension and edema associated with heart failure.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Bendroflumethiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1684. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2315. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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