Bromocriptine
A dopamine receptor agonist derived from ergot, used to treat Parkinson's disease, hyperprolactinemia, and as a unique oral medication for type 2 diabetes. In Parkinson's, it mimics dopamine to improve motor function; in diabetes, it works by resetting circadian metabolic rhythms in the brain. It can also be used to suppress lactation.
Peso Molecular
654,6000 g/mol
LogP
3,80
TPSA
118,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
InChI
InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1
Molecular Formula
C32H40BrN5O5
HBD / HBA
3 / 6
Ligações Rotacionáveis
5
Átomos Pesados
43
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A dopamine receptor agonist derived from ergot, used to treat Parkinson's disease, hyperprolactinemia, and as a unique oral medication for type 2 diabetes. In Parkinson's, it mimics dopamine to improve motor function; in diabetes, it works by resetting circadian metabolic rhythms in the brain. It can also be used to suppress lactation.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Bromocriptine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL493. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 31101. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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