Cephaloglycin
An early first-generation oral cephalosporin antibiotic with activity primarily against gram-positive bacteria, now obsolete and no longer in clinical use. It was one of the first cephalosporins developed for oral administration. It has been superseded by safer and more effective cephalosporin antibiotics.
Peso Molecular
405,4000 g/mol
LogP
-3,00
TPSA
164,00 Ų
Regra dos 5 de Lipinski
Aprovado
Mecanismo de Ação
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
InChI
InChI=1S/C18H19N3O6S/c1-9(22)27-7-11-8-28-17-13(16(24)21(17)14(11)18(25)26)20-15(23)12(19)10-5-3-2-4-6-10/h2-6,12-13,17H,7-8,19H2,1H3,(H,20,23)(H,25,26)/t12-,13-,17-/m1/s1
Molecular Formula
C18H19N3O6S
HBD / HBA
3 / 8
Ligações Rotacionáveis
7
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An early first-generation oral cephalosporin antibiotic with activity primarily against gram-positive bacteria, now obsolete and no longer in clinical use. It was one of the first cephalosporins developed for oral administration. It has been superseded by safer and more effective cephalosporin antibiotics.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cephaloglycin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200971. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 19150. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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