Chlorpropamide
A first-generation sulfonylurea oral antidiabetic drug that stimulates insulin secretion from pancreatic beta cells by closing ATP-sensitive potassium channels. It has an unusually long half-life that allows once-daily dosing but also increases the risk of prolonged hypoglycemia. It has largely been replaced by second-generation sulfonylureas and newer drug classes due to its side effect profile.
Peso Molecular
276,7400 g/mol
LogP
2,30
TPSA
83,70 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
InChI
InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
Molecular Formula
C10H13ClN2O3S
HBD / HBA
2 / 3
Ligações Rotacionáveis
4
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A first-generation sulfonylurea oral antidiabetic drug that stimulates insulin secretion from pancreatic beta cells by closing ATP-sensitive potassium channels. It has an unusually long half-life that allows once-daily dosing but also increases the risk of prolonged hypoglycemia. It has largely been replaced by second-generation sulfonylureas and newer drug classes due to its side effect profile.
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Yes, Chlorpropamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL498. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2727. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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