Cilastatin

CHEMBL766 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

358.5 g/mol

LogP

-1.0

Phase

4

A competitive inhibitor of the renal enzyme dehydropeptidase-I that degrades imipenem in the kidney, used exclusively in combination with imipenem to prevent renal inactivation and nephrotoxicity of the antibiotic. It has no intrinsic antibacterial activity of its own. The combination dramatically improves the pharmacokinetic profile and safety of imipenem.

Peso Molecular

358,5000 g/mol

LogP

-1,00

TPSA

155,00 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Infectious Disease Ovarian Cancer Hematology Oncology Obesity Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

CC1(C)C[C@@H]1C(=O)N/C(=C\CCCCSC[C@H](N)C(=O)O)C(=O)O

InChI

InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1

Molecular Formula

C16H26N2O5S

HBD / HBA

4 / 7

Ligações Rotacionáveis

11

Átomos Pesados

24

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A competitive inhibitor of the renal enzyme dehydropeptidase-I that degrades imipenem in the kidney, used exclusively in combination with imipenem to prevent renal inactivation and nephrotoxicity of the antibiotic. It has no intrinsic antibacterial activity of its own. The combination dramatically improves the pharmacokinetic profile and safety of imipenem.

Yes, Cilastatin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL766. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6435415. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

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Estrutura

Dados Rápidos

Fórmula: C16H26N2O5S
Sinônimos: 3

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.