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Cinacalcet Hydrochloride

CHEMBL1200776 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
393.9 g/mol
LogP
—
Phase
4

The hydrochloride salt form of cinacalcet is the standard oral preparation used in patients with chronic kidney disease on dialysis to control secondary hyperparathyroidism. It should be taken with food to maximize absorption. Nausea and vomiting are common initial side effects that often improve with dose titration.

Peso Molecular

393,9000 g/mol

TPSA

12,00 Ų

Áreas Terapêuticas

Cardiovascular Disease Osteoporosis Nephrology Chronic Kidney Disease Prostate Cancer

Mecanismo de Ação

Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.

Estrutura 2D

SVG PNG

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SMILES

                    
C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H23ClF3N

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Ligações Rotacionáveis

                        
6

                    

                    
                    
                    

                        
Átomos Pesados

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
The hydrochloride salt form of cinacalcet is the standard oral preparation used in patients with chronic kidney disease on dialysis to control secondary hyperparathyroidism. It should be taken with food to maximize absorption. Nausea and vomiting are common initial side effects that often improve with dose titration.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cinacalcet Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200776.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 156418.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.