Clonidine

CHEMBL134 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

230.1 g/mol

LogP

1.6

Phase

4

A centrally acting alpha-2 adrenergic agonist that lowers blood pressure by reducing sympathetic outflow from the brain, and is also used for ADHD, anxiety, and opioid withdrawal symptoms. It can be taken orally, as a skin patch, or injected.

Peso Molecular

230,0900 g/mol

LogP

1,60

TPSA

36,40 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Parkinson's Disease Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Obstetrics & Gynecology Chronic Kidney Disease Stroke Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain Heart Failure Prostate Cancer Colorectal Cancer

Mecanismo de Ação

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

Estrutura 2D

SVG PNG

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SMILES

Clc1cccc(Cl)c1NC1=NCCN1

InChI

InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)

Molecular Formula

C9H9Cl2N3

HBD / HBA

2 / 1

Ligações Rotacionáveis

2

Átomos Pesados

14

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A centrally acting alpha-2 adrenergic agonist that lowers blood pressure by reducing sympathetic outflow from the brain, and is also used for ADHD, anxiety, and opioid withdrawal symptoms. It can be taken orally, as a skin patch, or injected.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Clonidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL134. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 2803. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estrutura

Dados Rápidos

Fórmula: C9H9Cl2N3
Sinônimos: 9

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.