Deferasirox
An oral iron chelator that binds excess iron in the body and promotes its excretion in the feces, used to treat chronic iron overload from blood transfusions in conditions like thalassemia and sickle cell disease. It is taken once daily as a dispersible tablet or film-coated tablet.
Peso Molecular
373,4000 g/mol
LogP
3,80
TPSA
108,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1
InChI
InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
Molecular Formula
C21H15N3O4
HBD / HBA
3 / 6
Ligações Rotacionáveis
4
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An oral iron chelator that binds excess iron in the body and promotes its excretion in the feces, used to treat chronic iron overload from blood transfusions in conditions like thalassemia and sickle cell disease. It is taken once daily as a dispersible tablet or film-coated tablet.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Deferasirox is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL550348. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 214348. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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