Demecarium Bromide
The bromide salt of demecarium, a potent and long-acting anticholinesterase agent used as eye drops to lower intraocular pressure in glaucoma. It is rarely used today due to systemic toxicity risks and the availability of better-tolerated alternatives.
Peso Molecular
716,6000 g/mol
TPSA
59,10 Ų
Mecanismo de Ação
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CN(CCCCCCCCCCN(C)C(=O)Oc1cccc([N+](C)(C)C)c1)C(=O)Oc1cccc([N+](C)(C)C)c1.[Br-].[Br-]
InChI
InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2
Molecular Formula
C32H52Br2N4O4
HBD / HBA
- / 6
Ligações Rotacionáveis
17
Átomos Pesados
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
The bromide salt of demecarium, a potent and long-acting anticholinesterase agent used as eye drops to lower intraocular pressure in glaucoma. It is rarely used today due to systemic toxicity risks and the availability of better-tolerated alternatives.
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.
Yes, Demecarium Bromide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200514. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5965. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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