Desipramine
A tricyclic antidepressant and active metabolite of imipramine that primarily inhibits norepinephrine reuptake, used for major depression, neuropathic pain, and sometimes ADHD. It has fewer anticholinergic and sedative effects than many other tricyclic antidepressants.
Peso Molecular
266,4000 g/mol
LogP
4,90
TPSA
15,30 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CNCCCN1c2ccccc2CCc2ccccc21
InChI
InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
Molecular Formula
C18H22N2
HBD / HBA
1 / 2
Ligações Rotacionáveis
4
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A tricyclic antidepressant and active metabolite of imipramine that primarily inhibits norepinephrine reuptake, used for major depression, neuropathic pain, and sometimes ADHD. It has fewer anticholinergic and sedative effects than many other tricyclic antidepressants.
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Yes, Desipramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL72. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2995. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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