Deutetrabenazine

CHEMBL3137326 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

323.5 g/mol

LogP

2.9

Phase

4

A deuterium-substituted form of tetrabenazine that inhibits vesicular monoamine transporter 2 (VMAT2), reducing the amount of dopamine and other monoamines released at nerve terminals; used for chorea associated with Huntington's disease and tardive dyskinesia. The deuterium substitution slows metabolism, allowing twice-daily dosing.

Peso Molecular

323,5000 g/mol

LogP

2,90

TPSA

38,80 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Schizophrenia Bipolar Disorder Major Depressive Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

[2H]C([2H])([2H])Oc1cc2c(cc1OC([2H])([2H])[2H])C1CC(=O)C(CC(C)C)CN1CC2

InChI

InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/i3D3,4D3

Molecular Formula

C19H27NO3

HBD / HBA

- / 4

Ligações Rotacionáveis

4

Átomos Pesados

23

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A deuterium-substituted form of tetrabenazine that inhibits vesicular monoamine transporter 2 (VMAT2), reducing the amount of dopamine and other monoamines released at nerve terminals; used for chorea associated with Huntington's disease and tardive dyskinesia. The deuterium substitution slows metabolism, allowing twice-daily dosing.

Yes, Deutetrabenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3137326. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 73442840. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estrutura

Dados Rápidos

Fórmula: C19H27NO3
Sinônimos: 1

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.