Diethylcarbamazine Citrate
The citrate salt form of diethylcarbamazine, used in the treatment and prevention of filarial infections, most importantly lymphatic filariasis. This salt form is used in oral tablets and is the standard pharmaceutical preparation of the drug. The citrate salt improves stability and palatability of the medication.
Peso Molecular
391,4200 g/mol
TPSA
159,00 Ų
Mecanismo de Ação
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCN(CC)C(=O)N1CCN(C)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
InChI
InChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
Molecular Formula
C16H29N3O8
HBD / HBA
4 / 9
Ligações Rotacionáveis
7
Átomos Pesados
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
The citrate salt form of diethylcarbamazine, used in the treatment and prevention of filarial infections, most importantly lymphatic filariasis. This salt form is used in oral tablets and is the standard pharmaceutical preparation of the drug. The citrate salt improves stability and palatability of the medication.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Diethylcarbamazine Citrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL937. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 15432. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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