Difelikefalin
A kappa opioid receptor agonist that reduces itch signals without crossing into the brain, used to treat moderate-to-severe chronic kidney disease-associated pruritus in dialysis patients. It works peripherally to relieve the intense itching common in this condition.
Peso Molecular
679,8000 g/mol
LogP
-0,60
TPSA
223,00 Ų
Regra dos 5 de Lipinski
Reprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(C(=O)O)CC1
InChI
InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1
Molecular Formula
C36H53N7O6
HBD / HBA
7 / 9
Ligações Rotacionáveis
18
Átomos Pesados
49
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A kappa opioid receptor agonist that reduces itch signals without crossing into the brain, used to treat moderate-to-severe chronic kidney disease-associated pruritus in dialysis patients. It works peripherally to relieve the intense itching common in this condition.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Difelikefalin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989915. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 24794466. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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