Doxylamine
An antihistamine with sedating properties used to treat insomnia and, in combination with pyridoxine, to treat nausea and vomiting during pregnancy. It works by blocking histamine receptors in the brain.
Peso Molecular
270,3700 g/mol
LogP
2,50
TPSA
25,40 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCOC(C)(c1ccccc1)c1ccccn1
InChI
InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3
Molecular Formula
C17H22N2O
HBD / HBA
- / 3
Ligações Rotacionáveis
6
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An antihistamine with sedating properties used to treat insomnia and, in combination with pyridoxine, to treat nausea and vomiting during pregnancy. It works by blocking histamine receptors in the brain.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Doxylamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1004. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3162. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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