Eravacycline
This broad-spectrum tetracycline antibiotic works by blocking the machinery that bacteria use to make proteins, stopping them from growing and reproducing. It is used to treat complicated intra-abdominal infections caused by resistant bacteria.
Peso Molecular
558,6000 g/mol
LogP
1,00
TPSA
194,00 Ų
Regra dos 5 de Lipinski
Reprovado
Mecanismo de Ação
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)c(NC(=O)CN5CCCC5)cc(F)c4C[C@H]3C[C@@H]12
InChI
InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1
Molecular Formula
C27H31FN4O8
HBD / HBA
6 / 11
Ligações Rotacionáveis
5
Átomos Pesados
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This broad-spectrum tetracycline antibiotic works by blocking the machinery that bacteria use to make proteins, stopping them from growing and reproducing. It is used to treat complicated intra-abdominal infections caused by resistant bacteria.
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Yes, Eravacycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1951095. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54726192. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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