Fluticasone Furoate
This inhaled or intranasal corticosteroid reduces inflammation in the airways and nasal passages to control asthma and allergic rhinitis symptoms. It is a potent steroid with once-daily dosing due to its high receptor affinity and prolonged duration of action.
Peso Molecular
538,6000 g/mol
LogP
4,80
TPSA
119,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF
InChI
InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
Molecular Formula
C27H29F3O6S
HBD / HBA
1 / 10
Ligações Rotacionáveis
6
Átomos Pesados
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This inhaled or intranasal corticosteroid reduces inflammation in the airways and nasal passages to control asthma and allergic rhinitis symptoms. It is a potent steroid with once-daily dosing due to its high receptor affinity and prolonged duration of action.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Fluticasone Furoate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1676. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9854489. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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