Glyburide
A sulfonylurea medication that treats type 2 diabetes and gestational diabetes by stimulating the pancreas to release more insulin and making body cells more responsive to insulin's effects. It also has cardiovascular applications under investigation, including potential benefits in atrial fibrillation management. Blood sugar monitoring is essential as hypoglycemia is the most common serious side effect.
Peso Molecular
494,0000 g/mol
LogP
4,80
TPSA
122,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1
InChI
InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
Molecular Formula
C23H28ClN3O5S
HBD / HBA
3 / 5
Ligações Rotacionáveis
8
Átomos Pesados
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A sulfonylurea medication that treats type 2 diabetes and gestational diabetes by stimulating the pancreas to release more insulin and making body cells more responsive to insulin's effects. It also has cardiovascular applications under investigation, including potential benefits in atrial fibrillation management. Blood sugar monitoring is essential as hypoglycemia is the most common serious side effect.
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.
Yes, Glyburide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL472. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3488. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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